| Registro completo |
| Provedor de dados: |
ArchiMer
|
| País: |
France
|
| Título: |
Natural resistance to Fasciola hepatica (Trematoda) in Pseudosuccinea columella snails: A review from literature and insights from comparative “omic” analyses
|
| Autores: |
Alba, Annia
Tetreau, Guillaume
Chaparro, Cristian
Sánchez, Jorge
Vázquez, Antonio A.
Gourbal, Benjamin
|
| Data: |
2019-12
|
| Ano: |
2019
|
| Palavras-chave: |
Transcriptome
Albumen gland
Allocation of resources
Response to stress
Immune defense
Cost of resistance
|
| Resumo: |
The snail Pseudosuccinea columella is one of the main vectors of the medically-important trematode Fasciola hepatica. In Cuba, the existence of natural P. columella populations that are either susceptible or resistant to F. hepatica infection offers a unique snail-parasite for study of parasite-host compatibility and immune function in gastropods. Here, we review all previous literature on this system and present new “omic” data that provide a molecular baseline of both P. columella phenotypes from naïve snails. Comparison of whole snail transcriptomes (RNAseq) and the proteomes of the albumen gland (2D-electrophoresis, MS) revealed that resistant and susceptible strains differed mainly in an enrichment of particular biological processes/functions and a greater abundance of proteins/transcripts associated with immune defense/stress response in resistant snails. These results indicate a differential allocation of molecular resources to self-maintenance and survival in resistant P. columella that may cause enhanced responsiveness to stressors (i.e. F. hepatica infection or tolerance to variations in environmental pH/total water hardness), possibly as trade-off against reproduction and the ecological cost of resistance previously suggested in resistant populations of P. columella.
|
| Tipo: |
Text
|
| Idioma: |
Inglês
|
| Identificador: |
https://archimer.ifremer.fr/doc/00509/62039/66180.pdf
DOI:10.1016/j.dci.2019.103463
https://archimer.ifremer.fr/doc/00509/62039/
|
| Editor: |
Elsevier BV
|
| Formato: |
application/pdf
|
| Fonte: |
Developmental And Comparative Immunology (0145-305X) (Elsevier BV), 2019-12 , Vol. 101 , P. 103463 (14p.)
|
| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
|
